Finding the best ergonomic mouse for your needs and comfort doesn’t have to be a challenge. We’ve compiled a list of our top picks for the best ergonomic mouse, based on what tasks they help you perform, what position you want your wrist to be in, and what kind of functionality you might need in your new mouse. Whether you’re plugging away on the job, or you’re settling in for a long night of gaming fun, we’ve got you covered.

The true purpose of an ergonomic mouse is to provide comfortable, full-hand support for the user and encourage good forearm posture, while providing a solid input option for traditional computing tasks. With an expansive thumb rest and design that cushions and moulds to the palm, the MX Master 2S is a supremely comfortable and functional mouse.

The MX Master 2S sports a sensitivity of 4,000 DPI, and its wireless battery life of 70 days means you don’t need to worry about recharging the battery continually. With a great blend of features and comfort, it’s a fully-featured ergonomic mousing solution.

Exclusively available for right-hand users, the hand-sculpted design of the MX Master 2S is specially made to keep your wrist in as neutral a position as possible in the horizontal orientation. It uses a laser sensor (rather than optical), so it can track on any surface, recharges quickly (three minutes gives you a day of juice), and it can be paired over Bluetooth with up to three different devices.

Why we love it:

Many gaming mice use ambidextrous designs that are more catered to claw or finger-grip mouse styles, but there are a number that also offer good ergonomic support, and the Razer DeathAdder V2 is one of them. One of the best mice we have ever reviewed, it offers amazing features for gamers, while still providing decent support for your wrist and hand, no matter what your grip style may be.

Although it doesn’t have a rest for your thumb, it does have an indentation for you to grip with and there is plenty of shelf space for your fingers on the other side.

By virtue of being a gaming mouse first, this rodent has arguably the best specifications of all of the mice on this list. It sports a true 20,000 DPI optical sensor, with mechanical switches for long-life and support for Razer’s Chroma RGB lighting system. It also supports Razer’s powerful back-end software for key remapping and colour customisation.

Unlike many of the best ergonomic mice, Razer also produces a left-handed version of its DeathAdder Elite, too.

Why we love it:

If you’re looking for a uniquely shaped mouse, then you can bet on the J-Tech Digital Wired Ergonomic Mouse to impress. Its vertical design not only contours to the shape of your hand, but also helps reduce wrist and hand fatigue. The Scroll Endurance feature boasts adjustable sensitivity (DPI) and includes a detachable palm rest to reduce drag on your desktop. There are even two thumb buttons that are responsible for back/forward browser navigation functions.

Why we love it:

Taking a much more minimalist approach to ergonomic mouse design, Logitech’s M185 wireless mouse has a rounded design, intended to offer solid palm support without any extraneous features. It has a thumb rest to cushion your thumb into the side of the mouse, but it’s bulbous design, as we called it, is intended to teach you to lift your wrist off of your mat or desk when using it — encouraging the use of forearm muscles, rather than wrist tendons to support your hand.

Effectively, the M185 aims to have you do the hard work of supporting your wrist and mousing hand yourself, rather than acting as an overall supportive tool for you. The Logitech M185 has the usual pair of left/right-click buttons and a central scroll wheel that can move in four directions.

This wireless mouse is powered by just two AA batteries and connects up to your PC with ease, simply by plugging in the tiny nano receiver.

Why we love it:

Your wrists don’t care how expensive an ergonomic mouse is, which can be a problem for those who don’t want to spend a lot of cash on a mouse replacement. Fortunately, Trust’s solution is a great ergonomic model that’s as affordable a mouse as you can find. It offers options for 800, 1200 or 1600 DPI optical tracking that you can switch between to find the sensitivity that you like, and includes built in previous/next buttons for easy browsing — although they, like all six buttons on the mouse, can be mapped to different commands if you prefer.

While the mouse runs on 2 AAA battery, there are other options from this brand that are wired, providing full battery power, and can also support up to 2400 DPI, if that’s your fancy. While we’re fans of the truly ergonomic design that is created to prevent wrist and thumb pain, and the price is amazing, we should note that this mouse is a bit large. If you have especially small hands, it might prove difficult to use. It’s also right-handed only.

Why we love it:

When it comes to your comfort as well as your mousing performance, you need a mouse that will keep your wrist aligned and your clicking uninterrupted. An ergonomic mouse is not only great for increasing your overall performance when using it, but it also alleviates discomfort and pain caused by poor hand position that standard mice tend to require. Our ergonomic mice on this list will give you lasting comfort and ensure wrist health for years to come.