It’s no secret that the people are getting wider, heavier, and less healthy. Sloppy diets, lackluster exercise routines, and seemingly insurmountable daily stresses have led to an epidemic of “lifestyle diseases,” conditions caused by the way people live rather than the genes that make them up.
One of the most prevalent of these conditions is type II diabetes, afflicting tens of millions of Americans an imposing an annual cost of over $174 billion, according to the Center for Disease Control. If the problem goes unchecked, as many as a third of American adults could have diabetes by 2050.
Gastric bypass surgery has showed promise for diabetics — but it’s a major procedure with a host of potential complications and requires that a patient have a body mass index of at least 40. As a result, not a whole lot of patients opt in. Of the American’s who qualify, less than one or two percent undergo the operation.
But a study out this week in the journal Nature Materials offers a different approach that could prove to be a viable and less-invasive alternative to surgery. Simply by swallowing a pill before breakfast, lunch, or dinner, patients with type 2 diabetes may be able to coat their intestines with a thin layer, protecting them from blood sugar spikes.
“We envision a pill that a patient can take before a meal that transiently coats the gut to replicate the effects of surgery,” Jeff Karp, a Brigham and Women’s Hospital researcher who worked on the project, told Digital Trends. “During the past nine years, we’ve been working on this idea and have developed a safe gut-coating material that can potentially mimic the beneficial effects of gastric bypass procedures in the form a pill.”
Karp and his team needed a substance that could both coat the intestines and completely dissolve after its protective job was done. They settled on an FDA-approved substance called sucralfate, used to treat gastrointestinal ulcers. By engineering the compound further, they ended up with a substance they’ve called Luminal Coating of the Intestine (LuCI). Once ground into a dry powder, LuCI can be packaged into a pill.
Given to rodents, LuCI formed a thin layer over the animals’ intestines, providing a barrier for three hours from nutrients and helping regulate their blood sugar levels.
“LuCI can be activated in any part of the gastrointestinal tract … to form a temporary physical barrier that isolates that part of gastrointestinal tract,” Karp explained.
Moving forward, the researchers aim to test the substance for its long-term impact in a diabetic model. They hope to expand these trials to humans within the next year or two, with a best-case scenario seeing the treatment come to market in five years.
Google has been finding more ways to make Gemini a part of your daily routine, from putting together playlists to ordering groceries through your favorite apps. Now it's expanding those capabilities to more services, with Google Search joining in, too.
The company has announced a new Connected Apps Platform that makes it easier for developers to bring their services to both Gemini and Search. Alongside this, Google is adding new partners to its growing lineup, bringing more of the apps people already use into its AI ecosystem.
In the broad context of AI and its perceived harms, health and medical risks often pop up in the conversation. The warnings even come from frontier AI labs, such as ChatGPT-maker OpenAI and Anthropic, both of which have warned about misusing AI to cook up bioweapons. Security experts have already spotted a few such incidents in the wild, especially with the usage of AI models without any solid guardrails.
Well, it appears that the risks run deeper. As per an analysis appearing in the British Medical Journal (BMJ), AI bots are now being deployed to influence public policies governing health risks to citizens. In this instance, an attempt was made using AI bots to thwart regulations that aim to restrict the sale of disposable vapes, all while disguising the manipulation efforts as a response from real humans.
What if checking your drinking water for dangerous chemicals were as simple as plugging a tiny gadget into your smartphone? Researchers in Japan have developed a compact sensor that could make that possible, potentially bringing sophisticated water contamination testing out of expensive laboratories and into people's hands.
Scientists at the Okinawa Institute of Science and Technology (OIST) have created a portable device capable of detecting extremely low concentrations of PFAS, commonly known as "forever chemicals." The findings were published in the journal Biosensors and Bioelectronics, which demonstrate how an inexpensive sensor and a smartphone could make identifying potentially harmful chemicals in water a lot easier.