In the opening chapters of the Resident Evil 4 remake, you will come across strange shrines erected by a cult. These can be interacted with, but prompt you to use an item. Unfortunately, you won’t even have the chance to open the first couple you find since the item required to open them can’t be picked up until a bit later — and only if you know where to search for it. But it’s ro say that the treasures you get from them make it worth your time to backtrack and grab all the goodies inside. Here’s how you can open all the Wayshrines in the Resident Evil 4 remake, and what each one holds inside.
Surprise surprise, but Wayshrines can only be opened once you grab the Wayshrine Key. It will feel like a long time, but you can’t even access the key until you reach Chapter 4 and beat Del Lago. Once you can explore the lake, head south to the Mural Cave. Deep in the caves, you will find an ornate cabinet after solving the puzzle in the cave. You can get there by going down the path from the southern dock and through the section with the two large stone hands. Thankfully, unlike Small Keys, the Wayshrine Key is reusable and can open every Wayshrine in the game.
Now that you’ve got the Wayshrine Key, it’s time to do some backtracking to all those Wayshrines you were forced to pass by. In total, you will need to go back and open five to reap all the rewards. Here’s the location of each, as well as what treasures they hold for you:
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